Cotyledon orbiculata 'Pigs Ear' 5L plant

Native to South Africa,[1] it is popular in gardens in many countries. In the wild, it grows naturally in rocky outcrops in grassy shrubland and the Karoo region.

Cotyledon orbiculata has a number of medicinal uses. In South Africa, the fleshy part of the leaf is applied to warts and corns. Heated leaves are used as poultices for boils and other inflammations. Single leaves may be eaten as a vermifuge and the juice has been used to treat epilepsy.

However, the leaves contain a bufanolide called cotyledontoxin, which is toxic to sheep, goats, horses, cattle, poultry, and dogs, causing a condition known as cotyledonosis.